Dysmenorrhea – also known as painful menstrual cramps of uterine origin − is an extremely common gynecological complaint among women of reproductive age. In fact, it represents one of the most common causes of pelvic pain in young women and adolescents. It negatively affects women’s quality-of-life, and is the leading cause of absence from school and work among women in the reproductive age.1-4 Painful abdominal cramps, occurring with menstruation, are frequently accompanied by general premenstrual symptoms, such as nausea, vomiting, diarrhea, tiredness, dizziness, and headache. Importantly, dysmenorrhea is also associated with other pain conditions such as migraines, fibromyalgia, and irritable bowel syndrome. It has been found that women with dysmenorrhea, compared to those without, have enhanced pain sensitivity, which may render them more vulnerable to develop other chronic pain conditions later in life.