Liver function tests (LFTs) are one of the most commonly- requested screening blood tests. Whether for the investigation of suspected liver disease, monitoring of disease activity, or simply as ‘routine’ blood analysis, these tests can provide a host of information on a range of disease processes.1 Evaluation of abnormal liver enzyme levels in an otherwise healthy patient can pose a challenge to even an experienced clinician. Though, it may not be necessary to pursue extensive evaluation for all abnormal test results as they may not be directed towards actual liver diseases and can cause unnecessary concern and expose many patients to procedural risks and expenses. Conversely, failure to investigate mild or moderate liver enzyme elevations in turn increase the risk of missing the early diagnosis of potential life- threatening yet treatable conditions.