Primary pain disorders, which were formerly referred to as “functional pain syndromes”, are amongst the common, yet under-diagnosed and under-treated conditions in children and teenagers. Conservative estimates suggest that pediatric chronic pain affects 20% to 35% of children and adolescents worldwide. In fact, more than 10% of children admitted in hospital show features of chronic pain.1 The 2012 American Pain Society Position Statement, “Assessment and Management of Children with Chronic Pain” posited that chronic pain in children, when considered within a developmental trajectory, is the consequence of a dynamic integration of biological processes, psychological factors, and sociocultural variables.2 These determinants offer a clue that the chronic pain in youth may be associated with a variety of risk factors. The most striking evidence to date appears to support that temperament, anxiety, depression, subjective experience of stress, passive coping strategies, sleep problems, other somatic-related problems, and parent and/or family factors play significant role. As a result, chronic pain causes substantial functional impairment and is associated with other compromised outcomes, such as difficulty with school attendance and performance, problematic peer relationships, issues in family life, poor appetite and sleep, and low participation in pleasure activities.3 Features of an underlying pain vulnerability in pediatrics manifest in the three most common chronic pain disorders (as per locations), namely primary headaches, centrally mediated abdominal pain syndrome (CAPS), and/or chronic/recurrent musculoskeletal and joint pain.1 Centrally mediated abdominal pain syndrome is discussed in detail in the following section, under the most prevalent symptoms, manifestations, and its impact.