Clinical Presentation and Prevalence of Infantile Colic Infantile colic (IC) is a syndrome characterized by paroxysms of irritability and inconsolable crying and screaming, accompanied with associated motor behaviors such as clenched fists, drawn-up legs, and a red face. During the crying episodes, infant is generally inconsolable, which can be severely distressing for the parents. Hence, 10–20% of pediatrician visits of infants aged 2 weeks to 3 months is due to IC. Presentation of IC is usually seen in the second or third week after birth, and it peaks at 5 to 8 weeks of age.1 A plethora of studies have shown the prevalence of IC to be between 2% and 73% depending on study design, definition of colic, and method of data collection. For infants younger than 12 months of age, the prevalence is estimated between 2%- 73%. Additionally, occurrence of infantile colic in the first 3 months of life may range from 3% to 28% as shown by prospective studies and from 8% to 40% based on retrospective studies. Although IC usually resolves spontaneously by 4 months of age, it may have certain negative consequences as shown in Box 1.