Infant colic (IC) is considered to be a benign condition posing as a major burden to families, health care providers and the overall health system. Colic has been traditionally defined as a condition occurring in an otherwise healthy infant characterized by crying or fussing more than three hours a day and for more than three days a week.1 Later, IC was classified as a functional gastrointestinal disorder (FGID) characterized by the Rome III, and much later, the Rome IV criteria. According to the Rome III criteria, age of infants with colic range from birth to 4 months and they may present with paroxysmal symptoms of irritability, fussing/ crying in the absence of an obvious cause, episodes lasting for three hours a day or more. All symptoms are reported to occur at least three 3 days a week and last for at least a week. On the contrary, the Rome IV criteria for IC states that symptoms start and stop by 5 months of age. There are recurrent and extended periods of crying, fussing or irritability reported by caregivers with no evident cause and which are difficult-to-manage. The differences between Rome III and IV criteria for IC are described in table 1.