Infantile colic is a common, self-resolving condition seen in up to 20% of infants and characterized by excessive crying and irritability. Infantile colic is being described as excessive crying of unknown cause in otherwise well infants. It is often referred to a behaviour repertoire of early childhood with a distressing and puzzling character. Colic is traditionally defined by the Wessel’s criteria of crying or fussing >3 hours of the day for >3 days of the week. The new Rome IV criteria define it as ‘recurrent and prolonged periods of infant crying, fussing or irritability reported by caregivers that occur without obvious cause and cannot be prevented or resolved’. The condition is generally not perceived to be a serious problem, yet can be associated with a range of adverse outcomes for the infants (Box 1), besides the known inherent parental distress and concern arising from the excessive crying of the child, which consequently make them frequently seek medical consultation in the first few months of life. The diagnosis should be made after exclusion of potential organic causes. It usually resolves spontaneously after the first three to four months of life.