Dysuria is defined as pain, burning, or discomfort on urination which occurs more frequently due to UTI. It is more common in women than in men; more often in younger women, due to greater frequency of sexual activity. In men, older individuals are more likely to have dysuria because of an increased incidence of prostatic hyperplasia with accompanying inflammation and infection. Dysuria most often indicates infection or inflammation of the bladder and/or urethra. Other common causes of dysuria include prostatitis and mechanical irritation of the urethra in men, and urethrotrigonitis and vaginitis in women. Dysuria can also result from malformations of the genitourinary tract, neoplasms, neurogenic conditions, trauma, hormonal conditions, interstitial cystitis, and psychogenic disorders (Box 1).